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We're Getting Mutants in the MCU - The Loop
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Scutters is a pairing involving Butters Stotch and Scott Malkinson.
Origin
In "A Song of Ass and Fire", Butters and Scott are ordered by Cartman to go to George R.R. Martin's house and ask him to give up information about what happens next in Game of Thrones. Butters becomes very concerned with Scott as the latter is experiencing hypoglycemia due to having not eaten, and Martin's stalling because of his obsession with wieners in the show isn't helping matters.
Popularity
This pairing is rather rare, and some artwork and posts of it can be found on Tumblr.